期刊
VIRUS RESEARCH
卷 149, 期 1, 页码 119-123出版社
ELSEVIER
DOI: 10.1016/j.virusres.2010.01.005
关键词
Tahyna virus; Bunyavirus; California group; Genetic variability; Virulence
类别
资金
- Ministry of Education, Youth and Sports of the Czech Republic [Z60220518, MSM 6007665801, LC 06009]
Tahyna virus (TAHV), a mosquito-borne bunyavirus (California group), is frequently associated with inapparent or influenza-like (Valtice fever) infections in humans, rarely leading to atypical pneumonia or meningitis. Field TAHV strains exhibit a high variability in their biological properties with respect to virulence for laboratory mouse, temperature-sensitivity or character of plaques in cell culture. In consideration of the variations in the antigenic properties TAHV and its potential genetic variability, we analyzed complete nucleotide sequences of the small (S) and medium (M) genomic segments of field TAHV strains with different combinations of phenotypic markers. S segment was highly conservative in all analyzed TAHV strains. Within the M segment, the highest variability was observed in the G(C) gene encoding viral envelope protein and to a less extent also in the NSm gene. However, 5' and 3' non-coding regions of M segment, as well as in G(N) gene exhibited highly conservative pattern, indicating its functional importance, but minor or no role in the determination of biological properties of TAHV field strains. (C) 2010 Elsevier B.V. All rights reserved.
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