期刊
VIRUS RESEARCH
卷 139, 期 2, 页码 172-182出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2008.07.009
关键词
Internal translation initiation; Picornavirus infection; RNA structure; RNA-binding proteins; IRES transacting factors
类别
资金
- Funclacion Ramon Areces [BFU-200500948]
The RNA of all members of the Picornaviiidae family initiates translation internally, via an internal ribosome entry site (IRES) element present in their 5' untranslated region. IRES elements consist of cis-acting RNA structures that often operate in association with specific RNA-binding proteins to recruit the translational machinery. This specialized mechanism of translation initiation is shared with other viral RNAs, and represents an alternative to the general cap-dependent initiation mechanism. In this review we discuss recent evidences concerning the relationship between RNA structure and IRES function in the genome of picornaviruses. The biological implications of conserved RNA structural elements for the mechanism of internal translation initiation driven by representative members of enterovirus and rhinovirus (type I IRES) and cardiovirus and aphthovirus (type II IRES) will be discussed. (c) 2008 Elsevier B.V. All rights reserved.
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