期刊
VIRUS RESEARCH
卷 144, 期 1-2, 页码 225-232出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2009.05.004
关键词
Human influenza A H1N1 virus; Sialic acid; Ferret; Airways; Mucous cells; Metaplasia
类别
资金
- Danish Graduate School of Immunology
Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked alpha 2-3 and alpha 2-6 in the airways was investigated in infected and non-infected animals by use of sialic acid detecting lectins and a monoclonal antibody towards the Sialyl-Tn antigen. The goblet cells in the bronchi from non-infected ferrets expressed Sialyl alpha 2-6Gal glycans, while the seromucinous glands in the submucosa expressed Sialyl alpha 2-3Gal glycans. in the infected animals, the surface epithelial cells in some bronchi showed metaplasia and expressed the Sialyl-Tn antigen: Sialyl alpha 2-6GalNAc-O-Thr/Ser. The submucosal tracheal glands in these animals showed increased expression of both Sialyl alpha 2-3 and Sialyl alpha 2-6 epitopes. (C) 2009 Elsevier B.V. All rights reserved.
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