期刊
VIRUS RESEARCH
卷 139, 期 2, 页码 230-239出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.virusres.2008.07.016
关键词
Flavivirus; Genome cyclization; Viral RNA synthesis; Viral cis-acting elements; RNA-RNA interactions; Viral UTRs
类别
资金
- NIAID NIH HHS [R01 AI095175] Funding Source: Medline
Long-range and local RNA-RNA contacts in viral RNA genomes result in tertiary structures that modulate the function of enhancers, promoters, and silencers during translation, RNA replication. and encapsidation. In the case of flaviviruses, the presence of inverted complementary sequences at the 5' and 3' ends of the genome mediate long-range RNA interactions and RNA cyclization. The circular conformation of flavivirus genomes was demonstrated to be essential for RNA amplification. New ideas about the mechanisms by which circular genomes participate in flavivirus replication have emerged in the last few years. Here, we will describe the latest information about cis-acting elements involved in flavivirus genome cyclization, RNA promoter elements required for viral polymerase recognition, and how these elements together coordinate viral RNA synthesis. (c) 2008 Elsevier B.V. All rights reserved
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