期刊
VIRUS RESEARCH
卷 139, 期 1, 页码 122-126出版社
ELSEVIER
DOI: 10.1016/j.virusres.2008.10.001
关键词
Human adenovirus type 19; Epidemic keratoconjunctivitis; Genome
类别
资金
- NIH [EY013124, EY015222, EY012190, P20 RR017703, P20 RR015564, T32 A1007633]
- Research to Prevent Blindness Physician-Scientist Merit Award
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR017703, P20RR015564] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R03EY015222, P30EY012190, R01EY013124] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [T32AI007633] Funding Source: NIH RePORTER
Human adenovirus type 19 (HAdV-19) is a major etiologic agent of epidemic keratoconjunctivitis (EKC), a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation. Ironically, while the prototype strain of HAdV-19 does not cause eye infections, other isolates of the serotype have caused major outbreaks of EKC. Here we have sequenced a clinical isolate of HAdV-19 (HAdV-19 strain C) from a human patient with EKC. Global pairwise alignment of HAdV-19C to other HAdV species D serotypes identified areas of sequence divergence in the penton base (host cell internalization signal), hexon (principal viral capsid structural protein), E3 (site of immunomodulatory genes), and fiber (host cell-binding ligand) regions. Comparison of HAdV-19 strain C to the recently sequenced HAdV-37, another EKC causing serotype, identified sequence diversity in the penton base and hexon, but sequence conservation in the E3 and fiber regions. Elucidation of the HAdV-19C genome will facilitate future studies into the pathogenesis of EKC, and may shed light on the genetic determinants of corneal tropism. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据