期刊
VIRUS GENES
卷 42, 期 1, 页码 46-54出版社
SPRINGER
DOI: 10.1007/s11262-010-0545-9
关键词
RSV; G glycoprotein; Influenza; Cellular immunity; Vaccines
资金
- Linda and Timothy O'Neill Institute at Georgetown University [AI-054952]
- Thrasher Research Fund
- Fogarty International Center at Vanderbilt [R24 TW007988]
- CONICET, Argentina
The cytotoxic T-lymphocyte (CTL) response plays an important role in the control of respiratory syncytial virus (RSV) replication and the establishment of a Th1-CD4+ T cell response against the virus. Despite lacking Major Histocompatibility Complex I (MHC I)-restricted epitopes, the attachment G glycoprotein of RSV enhances CTL activity toward other RSV antigens, and this effect depends on its conserved central region. Here, we report that RSV-G can also improve CTL activity toward antigens from unrelated pathogens such as influenza, and that a mutant form of RSV-G lacking four conserved cysteine residues at positions 173, 176, 182, and 186 fails to enhance CTL responses. Our results indicate that these conserved residues are essential for the wide-spectrum pro-CTL activity displayed by the protein.
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