期刊
VIROLOGY JOURNAL
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/1743-422X-7-172
关键词
-
类别
资金
- Helmholtz-Association
- FluResearchNet [01KI07137]
- German Ministry of Education and Research [01GS0855]
- Helmholtz-China Scholarship Council
The importance of the adaptive immune response for secondary influenza infections and protection from a lethal challenge after vaccination has been well documented. However, some controversy still exists concerning the specific involvement of B and T cells during a primary infection. Here, we have followed the survival, weight loss, viral load and lung pathology in Rag2-/- knock-out mice after infection with influenza A virus (H1N1). Infected wild type mice initially lost weight early after infection but then cleared the virus and recovered. Rag2-/- mice, however, showed similar weight loss kinetics in the early stages after infection but weight loss continued post infection and culminated in death. In contrast to wild type mice, Rag2-/- mice were not able to clear the virus, despite an increased inflammatory response. Furthermore, they did not recruit virus-specific lymphocytes into the lung in the later stages after infection and exhibited sustained pulmonary lesions.
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