期刊
VIROLOGY
卷 452, 期 -, 页码 297-302出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.01.022
关键词
Antiviral activity; Bovine lactoferrin; Mayaro virus
类别
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq),
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
- Financiadora de Estudos e Projetos (FINEP)
- Instituto Nacional de Ciencia e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)
- Programa de Apoio a Nucleos de Excelencia (PRONEX)
Mayaro virus (MAYV) is an arbovirus linked to several sporadic outbreaks of a highly debilitating febrile illness in many regions of South America. MAYV is on the verge of urbanization from the Amazon region and no effective antiviral intervention is available against human infections. Our aim was to investigate whether bovine lactoferrin (bLf), an iron-binding glycoprotein, could hinder MAYV infection. We show that bLf promotes a strong inhibition of virus infection with no cytotoxic effects. Monitoring the effect of bLf on different stages of infection, we observed that virus entry into the cell is the heavily compromised event. Moreover, we found that binding of bLf to the cell is highly dependent on the sulfation of glycosaminoglycans, suggesting that bLf impairs virus entry by blocking these molecules. Our findings highlight the antiviral potential of bLf and reveal an effective strategy against one of the major emerging human pathogens in the neotropics. (C) 2014 Elsevier Inc. All rights reserved.
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