期刊
VIROLOGY
卷 458, 期 -, 页码 151-161出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2014.04.022
关键词
Human cytomegalovirus; P-body; Stress granule; Translation; Eukaryotic initiation factor; Translation initiation; MRNA decay
类别
资金
- [24659309]
- [24790395]
- Grants-in-Aid for Scientific Research [24659309] Funding Source: KAKEN
Translationally silenced mRNAs are recruited to two major classes of RNA granules in the cytoplasm, processing bodies (PBs) and stress granules (SGs). We show that PBs accumulated after human cytomegalovirus (HCMV) infection. PB assembly after HCMV infection was also detected in the presence of the protein synthesis inhibitor, cycloheximide, but required active RNA synthesis. UV-inactivated HCMV virions were sufficient to induce PB accumulation in HFF cells treated with cycloheximide. Viral IE1 RNA did not colocalize with PBs, and we could not detect an effect of PB accumulation on viral growth. These results may indicate that HCMV inhibits the colocalization of IE1 mRNA with PBs, preventing IE1 mRNA decay and translational inhibition. (C) 2014 Elsevier Inc. All rights reserved.
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