期刊
VIROLOGY
卷 435, 期 1, 页码 37-45出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.10.005
关键词
Natural killer (NK) cells; T cells; NK cell receptors (NKR); 2B4; Lymphocytic choriomeningitis virus (LCMV); Murine cytomegalovirus (MCMV); Persistent infection; Pathogenesis; Interferon; Cytotoxic
类别
资金
- NIH [T32 AI07349, AI017672, CA34461, AI081675, AI046629]
- Ellison Medical Foundation
Viral infections characteristically induce a cytokine-driven activated natural killer (NK) cell response that precedes an antigen-driven T cell response. These NK cells can restrain some but not all viral infections by attacking virus-infected cells and can thereby provide time for an effective T cell response to mobilize. Recent studies have revealed an additional immunoregulatory role for the NK cells, where they inhibit the size and functionality of the T cell response, regardless of whether the viruses are themselves sensitive to NK cells. This subsequent change in T cell dynamics can alter patterns of immunopathology and persistence and implicates NK cells as rheostat-like regulators of persistent infections. (C) 2012 Elsevier Inc. All rights reserved.
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