期刊
VIROLOGY
卷 438, 期 1, 页码 1-4出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.12.016
关键词
microRNA; miR-132; HIV; MeCP2
类别
资金
- National Institute on Drug Abuse [5R21DA030166-03]
- BCM Cytometry and Cell Sorting Core
- NIH (NCRR) [S10RR024574]
- NIH (NIAID) [AI036211]
- NIH (NCI) [P30CA125123]
MicroRNAs upregulated during CD4(+) T cell activation may contribute to the increased efficiency of HIV-1 replication seen following perturbation of the resting state. We have found miR-132 to be highly upregulated following CD4(+) T cell activation, and show that miR-132 potentiates viral replication in the Jurkat CD4(+) T cell line. Knockdown of MeCP2, a previously identified target of miR-132, also increases HIV-1 replication. To the best of our knowledge, miR-132 is the first miRNA reported to enhance HIV-1 replication. (C) 2013 Elsevier Inc. All rights reserved.
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