期刊
VIROLOGY
卷 436, 期 2, 页码 295-303出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.12.005
关键词
Polyomavirus; Virus discovery; Tumor antigen; Alternative splicing; Recombination
类别
资金
- NIH [U54 AI057160, K24 DK002886, DK079333]
- Roche Organ Transplantation Foundation
- Medical Research Council (UK)
- Bill & Melinda Gates Foundation [OPP1016839]
- Bill and Melinda Gates Foundation [OPP1016839] Funding Source: Bill and Melinda Gates Foundation
The family Polyomaviridae is comprised of circular double-stranded DNA viruses, several of which are associated with diseases, including cancer, in immunocompromised patients. Here we describe a novel polyomavirus recovered from the fecal microbiota of a child in Malawi, provisionally named STL polyomavirus (STLPyV). We detected STLPyV in clinical stool specimens from USA and The Gambia at up to 1% frequency. Complete genome comparisons of two STLPyV strains demonstrated 5.2% nucleotide divergence. Alternative splicing of the STLPyV early region yielded a unique form of T antigen, which we named 229T, in addition to the expected large and small T antigens. STLPyV has a mosaic genome and shares an ancestral recombinant origin with MWPyV. The discovery of STLPyV highlights a novel alternative splicing strategy and advances our understanding of the complex evolutionary history of polyomaviruses. (c) 2012 Elsevier Inc. All rights reserved.
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