Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue

The HPV16 E7 oncoprotein and 17 beta-estradiol are important factors for the induction of premalignant lesions and cervical cancer. The study of these factors is crucial for a better understanding of cervical tumorigenesis. Here, we assessed the global gene expression profiles induced by the HPV16 E7 oncoprotein and/or 17 beta-estradiol in cervical tissue of FvB and K14E7 transgenic mice. We found that the most dramatic changes in gene expression occurred in K14E7 and FvB groups treated with 17 beta-estradiol. A large number of differentially expressed genes involved in the immune response were observed in 17 beta-estradiol treated groups. The E7 oncoprotein mainly affected the expression of genes involved in cellular metabolism. Our microarray data also identified differentially expressed genes that have not previously been reported in cervical cancer. The identification of genes regulated by E7 and 17 beta-estradiol, provides the basis for further studies on their role in cervical carcinogenesis. (C) 2013 Elsevier Inc. All rights reserved.