期刊
VIROLOGY
卷 445, 期 1-2, 页码 169-174出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2013.05.038
关键词
HPV; HPV16; Virion; Papillomaviridae; L2; Maturation
类别
资金
- Intramural Research Program of the NIH
- Center for Information Technology (CIT)
- National Cancer Institute's Center for Cancer Research
- National Institute of Arthritis, Musculoskeletal and Skin Diseases
The elegant icosahedral surface of the papillomavirus virion is formed by a single protein called Ll. Recombinant Ll proteins can spontaneously self-assemble into a highly immunogenic structure that closely mimics the natural surface of native papillomavirus virions. This has served as the basis for two highly successful vaccines against cancer-causing human papillomaviruses (HPVs). During the viral life cycle, the capsid must undergo a variety of conformational changes, allowing key functions including the encapsidation of the similar to 8 kb viral genomic DNA, maturation into a more stable state to survive transit between hosts, mediating attachment to new host cells, and finally releasing the viral DNA into the newly infected host cell. This brief review focuses on conserved sequence and structural features that underlie the functions of this remarkable protein. (C) 2013 Elsevier Inc. All rights reserved.
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