期刊
VIROLOGY
卷 433, 期 1, 页码 220-225出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2012.08.014
关键词
Kaposi sarcoma-associated herpesvirus; KSHV; HHV8; HHV6; AIDS; KICS
类别
资金
- NIH [DE018304, CA109232]
- NCI [AI50410]
- University Cancer Research Fund (UCRF)
- [T32 GM07092-34]
KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a. The HHV8 plasma viral load was 5,300,000 copies/ml, which is the highest reported to date; this despite less than five skin lesions and no HHV8 associated lymphoma. This is the first report of systemic HHV6a/KSHV co-infection in a patient. It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated with KSHV. (C) 2012 Elsevier Inc. All rights reserved.
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