期刊
VIROLOGY
卷 424, 期 2, 页码 77-98出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.12.018
关键词
Human papillomaviruses; HPV E6; HPV E7; HPV E5; HPV cellular transformation; HPV and differentiation; HPV pathogenesis; HPV life cycle; Rb; p53
类别
资金
- NIA NIH HHS [R01 AG027388] Funding Source: Medline
- NIDCR NIH HHS [R21 DE019953] Funding Source: Medline
The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s yet the mechanisms of virally-mediated cellular transformation are still being revealed. Reasons for this include: a) the oncoproteins are multifunctional, b) there is an ever-growing list of cellular interacting proteins, c) more than one cellular protein may bind to a given region of the oncoprotein, and d) there is only limited information on the proteins encoded by the corresponding non-oncogenic PVs. The perspective of this review will be to contrast the activities of the viral E6 and E7 proteins encoded by the oncogenic human PVs (termed high-risk HPVs) to those encoded by their non-oncogenic counterparts (termed low-risk HPVs) in an attempt to sort Out viral life cycle-related functions from oncogenic functions. The review will emphasize lessons learned from the cell culture studies of the HPVs causing mucosal/genital tract cancers. (C) 2011 Elsevier Inc. All rights reserved.
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