期刊
VIROLOGY
卷 411, 期 2, 页码 273-287出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.12.007
关键词
Retroelement; Endogenous retrovirus (ERV); Long interspersed nuclear element (LINE); Intracisternal A particle (IAP); Cytosine methylation; Histone methylation; Kruppel-associated box domain-zinc finger protein (KRAB-ZFP); KRAB-associated protein 1 (KAP1); Development
类别
资金
- Swiss National Science Foundation
- European Research Council
- Infectigen Association
- Strauss Foundation
Close to half of the human genome encompasses mobile genetic elements, most of which are retro-transposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving the ability to induce new integrants within their hosts' genome. Expectedly, the control of endogenous retroviruses is tight and multi-pronged. It is most crucially established in the germ line and during the first steps of embryogenesis, primarily through transcriptional mechanisms that have likely evolved under their very pressure, but are now engaged in controlling gene expression at large, notably during early development. (C) 2010 Elsevier Inc. All rights reserved.
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