期刊
VIROLOGY
卷 411, 期 2, 页码 344-354出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.12.041
关键词
HIV reservoirs; HIV latency; Resting CD4+T cell; HIV latency models; Ongoing replication; Latently infected cells; Reservoir maintenance; Persistence; Reservoir formation; HAART
类别
资金
- NIAID NIH HHS [R21 AI087461, K02 AI078766-03, K02 AI078766-04, R21 AI081215-02, K02 AI078766-05, K02 AI078766, R21 AI081215, R21 AI087461-02, R21 AI087461-01A1] Funding Source: Medline
The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells. In addition, we compare several different in vivo and in vitro models of latency. We comment on how each model may reflect the properties of reservoirs in vivo, especially with regard to cell phenotype, since recent studies demonstrate that multiple CD4+ T cell subsets contribute to HIV reservoirs and that with HAART and disease progression the relative contribution of different subsets may change. Finally, we focus on the direct infection of resting CD4+ T cells as a source of reservoir formation and as a model of latency, since recent results help explain the misconception that resting CD4+ T cells appeared to be resistant to HIV in vitro. (C) 2011 Elsevier Inc. All rights reserved.
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