期刊
VIROLOGY
卷 420, 期 2, 页码 125-134出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2011.09.001
关键词
Influenza virus; Replication; Swine; Dendritic cells
类别
资金
- Spanish Government [CSD 2006-00007, AGL2006-13809-C03-01, AGL2009-12945-C02-01, AGL2010-22200-C02-01]
- AECID
- Spanish Ministry of Science and Innovation
Swine influenza virus (SwIV) causes sub-acute or acute respiratory infections on swine farms and pigs can act as mixing vessels for new influenza strains. Knowledge of the immune response of SwIV in its natural host, pigs, is very limited. Dendritic cells (DCs) mediate the induction of immunity to pathogens, but their interaction with SwIV has not been fully characterized. Thus, porcine bone marrow derived DCs (poBMDCs) were exposed to a circulating strain of H3N2 SwIV in vitro. Infection of poBMDCs resulted in structures resembling influenza virus inside poBMDCs in vesicles and also free in cytoplasm. Viral progeny was undetectable in supernatant but limited replication was detected in the first 8 h after infection. However, viral particles from infected-poBMDCs were able to induce cytopathic effect in susceptible cells only when cell-to-cell interaction was favoured. The data generated in our studies reveal the particular interaction of H3N2 SwIV with conventional DCs. (C) 2011 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据