期刊
VIROLOGY
卷 400, 期 2, 页码 215-223出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.01.035
关键词
Bovine foamy virus; BTas; NF-kappa B pathway; Viral transcription
类别
资金
- Chinese Ministry of Health [2008ZX 10001-002]
- National Natural Science Foundation of China [30770097]
- National Basic Research Program of China [2005CB522903]
Multiple families of viruses have evolved sophisticated strategies to regulate nuclear factor-kappa B (NF-kappa B) signaling, which plays a pivotal role in diverse cellular events, including virus-host interactions. In this study, we report that bovine foamy virus (BFV) is able to activate the NF-kappa B pathway through the action of its transactivator, BTas. Both cellular IKK beta and I kappa B alpha also participate in this activation. In addition, we demonstrate that Bias induces the processing of p100, which implies that Bias can activate NF-kappa B through a noncanonical pathway as well. Co-immunoprecipitation analysis shows that BTas interacts with IKK catalytic subunits (IKK alpha and IKK beta), which may be responsible for regulation of IKK kinase activity and persistent NF-kappa B activation. Furthermore, our results indicate that the level of Bias-mediated LTR transcription correlates with the activity of cellular NF-kappa B. Together, this study suggests that BFV activates the NF-kappa B pathway through Bias to enhance viral transcription. (C) 2010 Elsevier Inc. All rights reserved.
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