期刊
VIROLOGY
卷 407, 期 2, 页码 381-390出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.08.036
关键词
Staphylococcus aureus; Pathogenicity island; Helper phage; Phage packaging; Derepression; Horizontal gene transfer; Genome sequence comparison; Transduction
类别
资金
- National Institutes of Health [R01AI22159, R21AI067654]
- A.D. Williams Trust
- Baruch Foundation Trust
- NSF [EEC02341014]
- NIH Bioinformatics and Bioengineering Summer Institute
- NIH MSTP [5T32 GM07308]
- VCU College of Humanities and Science
Staphylococcus aureus pathogenicity islands (SaPIs) are mobile elements that are induced by a helper bacteriophage to excise and replicate and to be encapsidated in phage-like particles smaller than those of the helper, leading to high-frequency transfer. SaPI mobilization is helper phage specific: only certain SaPIs can be mobilized by a particular helper phage. Staphylococcal phage 80 alpha can mobilize every SaPI tested thus far, including SaPI1, SaPI2 and SaPIbov1. Phage 80, on the other hand, cannot mobilize SaPI1, and phi 11 mobilizes only SaPIbov1. In order to better understand the relationship between SaPIs and their helper phages, the genomes of phages 80 and 80 alpha were sequenced, compared with other staphylococcal phage genomes, and analyzed for unique features that may be involved in SaPI mobilization. (C) 2010 Elsevier Inc. All rights reserved.
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