期刊
VIROLOGY
卷 401, 期 1, 页码 1-5出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.02.024
关键词
Influenza virus; Pathogenicity; Virulence; PB2 627 residue; Temperature-sensitivity
类别
资金
- Li Ka Shing Foundation
- University Grants Committee of the Hong Kong SAR [AoE/M-12/06]
- Research Grant Council of Hong Kong SAR [HKU 7488/05M, 7500/06M]
- National Institutes of Health(NIH) [HSN266200700005C]
A lysine at the 627 position (627K) of PB2 protein of influenza virus has been recognized as a determinant for host adaptation and a virulent element for some influenza viruses. While seasonal influenza viruses exclusively contained 627K, the pandemic (H1N1) 2009 possessed a glutamic acid (627E), even after circulation in humans for more than 6 months. To explore the potential role of E627K substitution in PB2 in the pandemic (H1N1) 2009 virus, we compared pathogenicity and growth properties between a recombinant virus containing 627K PB2 gene and the parental A/California/4/2009 strain containing 627E. Our results showed that substitution of 627K in PB2 gene does not confer higher virulence and growth rate for the pandemic (H1N1) 2009 virus in mice and cell culture respectively, suggesting 627K is not required for human adaptation of the pandemic (H1N1) 2009 virus. (C) 2010 Elsevier Inc. All rights reserved.
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