期刊
VIROLOGY
卷 405, 期 1, 页码 62-69出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2010.05.002
关键词
Avian influenza virus; Chicken T lymphocytes; Adenovirus vectors; Influenza hemagglutinin; Influenza nucleocapsid; Memory T lymphocytes; Effector T lymphocytes
类别
资金
- USDA [2006-35204-16560, 2005-35605-15388]
- NIH [R43 AI068285-01]
Avian influenza virus (AIV) specific CD8(+) T lymphocyte responses stimulated by Intramuscular administration of an adenovirus (Ad) vector expressing either HA or NP were evaluated in chickens following ex vivo stimulation by non-professional antigen presenting cells The CD8(+) T lymphocyte responses were AIV specific, MHC-I restricted, and cross-reacted with heterologous H7N2 AIV strain. Specific effector responses, at 10 days post-inoculation (p i), were undetectable at 2 weeks p.i and memory responses were detected from 3 to 8 weeks pi Effector memory responses, detected 1 week following a booster inoculation, were significantly greater than the primary responses and. within 7 days, declined to undetectable levels Inoculation of an Ad-vector expressing human NP resulted in significantly greater MHC restricted, activation of CD8(+) T cell responses specific for AIV Decreases in all responses with time were most dramatic with maximum activation of T cells as observed following effector and effector memory responses (C) 2010 Elsevier Inc All rights reserved
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