期刊
VIROLOGY
卷 391, 期 1, 页码 73-82出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.05.022
关键词
HIV-1 Genetic variation Evolution LTNPs; Ancestral LTNP; Modern LTNP; HIV controllers; Elite controllers; Viral DNA; Deletions; Complete genome sequence; Host factors; HLA
类别
资金
- Plan Nacional del SIDA [SAF 2005/03833, SAF 2007-61036]
- Red Tematica Cooperativa de Investigacion en SIDA (Red de grupos 173)
- Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss)
We studied viral evolution in three HIV-1 ancestral patients from a group of LTNPs: although some minor sequences showing viral evolution were detected in all patients, the extremely low viral evolution of their Viruses was shown by the phylogenetic analysis of the env sequences. Complete nucleotide sequencing of viral DNA showed the major presence of deletions. In two patients, deletions of 1088 and 228 nucleotides mapped to 51 LTR-gag region: in the other, a 247 nucleotide deletion was positioned in pol gene Up to the vif ORE. These deleted genomes became dominant during Follow LIP. Patient's viruses displayed 13 common mutations in conserved residues, from the 5' LTR to the nef gene. These mutations provided evidence of a common origin. Regarding host characteristics, one patient had HLA B2705/B5801: another B1402/B5701: whereas a third showed B3901/B4402 and was Delta 32-CCR5 heterozygous. These HIV controllers presented a combination of deleted viral genomes and host protective factors. (C) 2009 Elsevier Inc. All Lights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据