期刊
VIROLOGY
卷 387, 期 2, 页码 388-394出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2009.02.024
关键词
HIV; Mother-to-child transmission; Neutralizing antibodies
类别
资金
- Agence Nationale de Recherches Sur le Sida (ANRS, Paris, France)
- Sidaction (Paris, France)
- Institut de Recherche pour le Developpement (IRD, Paris, France)
- National Institutes of Health [5 R01 HD 33326]
- French Ministry of Foreign Affairs
Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing HIV infection. We determined the titers of neutralizing antibodies (NAbs) against six primary isolates of clades B and CRF01_AE in sera from 45 transmitting and 45 nontransmitting mothers matched for the main independent factors associated with MTCT in Thailand. A lower risk of MTCT, particularly for intrapartum transmission, was associated only with higher NAb titers against the CRF01_AE strain, MBA. The envelope glycoprotein of this strain showed an unusually long V2 domain of 63 amino acids, encoding six potential N-linked glycosylation sites. We provided experimental data indicating that the extended V2 domain contributed to the higher level of resistance to neutralization by mothers' sera in this strain. Taken together the data suggest that some primary isolates with specific properties may be useful indicators for identifying protective antibodies. (C) 2009 Elsevier Inc. All Fights reserved.
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