期刊
VIROLOGY
卷 384, 期 2, 页码 335-344出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.10.006
关键词
Human papillomavirus; E7 oncoprotein; Cellular transformation; Retinoblastoma tumor suppressor; p53; Genomic instability; Centrosome duplication; Ubiquitin ligase; Cell death; Cellular metabolism
类别
资金
- NIH [R01 CA066980, R01 CA081135]
- American Cancer Society [PF-07-072-01-MBC]
The human papillomavirus (HPV) E7 oncoprotein shares functional similarities with such proteins as adenovirus E1A and SV40 large tumor antigen. As one of only two viral proteins always expressed in HPV-associated cancers, E7 plays a central role in both the viral life cycle and carcinogenic transformation. in the HPV viral life cycle, E7 disrupts the intimate association between cellular differentiation and proliferation in normal epithelium, allowing for viral replication in cells that Would no longer be in the dividing population. This function is directly reflected in the transforming activities of E7, including tumor initiation and induction of genomic instability. (C) 2008 Elsevier Inc. All rights reserved.
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