期刊
EXPERT REVIEW OF NEUROTHERAPEUTICS
卷 15, 期 8, 页码 947-959出版社
EXPERT REVIEWS
DOI: 10.1586/14737175.2015.1065180
关键词
antiepileptic drugs; electroencephalogram; focal epilepsy; hippocampal slices; interictal epileptiform discharges; temporal lobe epilepsy
资金
- Janssen
- UCB
- Eisai
- Novartis
- Biogen
- Merck-Serono
- Teva
- Cyberonics
- AIFA
Interictal epileptiform discharges (IEDs), occurring in the electroencephalograms (EEG) of patients with focal epilepsy, are crucial for diagnosis, while their relationship with seizure severity and recurrence is controversial. The effects of antiepileptic drugs (AEDs) on IEDs are even more debated. In general, it is currently believed by experts in the field that most of the classical AEDs do not significantly affect IEDs occurrence in these patients, and that monitoring their EEG effects during treatment is useless. In this review, we update the existing literature on the effects of classical and newer AEDs on focal IEDs, emphasizing the scarcity of data concerning the latter. We also discuss potential limits of available clinical and experimental data and future perspectives.
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