期刊
VIROLOGY
卷 375, 期 2, 页码 492-503出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2008.01.040
关键词
repeated challenges; low-dose; Cervico-vaginal lavage; T-cell responses; mucosal cytokines; SHIV infection; DC-SIGN
类别
Local and systemic immunological changes following vaginal HIV-1 exposures are poorly characterized and may influence susceptibility to infection. Therefore, we examined longitudinal mucosal, plasma cytokine profiles and viral-specific T-cell responses (vSTRs) before and during weekly repeated low-dose SHIVSF162P3 viral challenges in six female pigtailed macaques, even in the absence of overt systemic infection. Following a single viral challenge, induction of several cytokines was detected consistently in cervico-vaginal lavages (CVL). With additional exposure and documented systemic infection, a hallmark of response profile was defined as peak levels in both CVL (MCP-1, MIP-1 alpha, TNF-alpha, IL-1 beta , IL-1RA and IL-8) and plasma cytokines (MCP-1, eotaxin and IL- IRA) in the macaques. In the periphery, vSTRs were observed within the first one or two viral challenges, but prior to the detection of systemic infection in 5/6 exposed pigtailed macaques. These findings provide valuable information regarding mucosal HIV-1 infection that may benefit microbicide research and development. Published by Elsevier Inc.
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