期刊
VIRCHOWS ARCHIV
卷 459, 期 4, 页码 361-366出版社
SPRINGER
DOI: 10.1007/s00428-011-1140-8
关键词
Tumor-associated macrophages; M1 type; M2 type; Hodgkin lymphoma; Immunohistochemistry; Double staining; Prognosis
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [20590364, 20014010]
- Grants-in-Aid for Scientific Research [23790398, 20590364, 20014010] Funding Source: KAKEN
To evaluate roles of tumor-associated macrophages (TAMs) for prognosis of classical Hodgkin lymphoma (CHL). Expression of markers for TAMs, CD68, HLA-DR, CD163, HLA-DR/CD68 (M1), and CD163/CD68 (M2) was immunohistochemically examined in 82 cases with CHL. Positively stained cells were counted and correlation of number of TAMs and patients' survival time was analyzed. Number of CD163+ cells and M2 cells was significantly correlated with shorter overall survival (P < 0.05), while it was marginally significant for CD68+ cells (P = 0.0827). HLA-DR + cells and M1 cells showed no significant correlation with overall survival. When confined to mixed cellularity subtype, number of M1 cells was correlated with favorable prognosis (P < 0.05), while M2 did not (P = 0.7). Older age and male sex were unfavorable factors for prognosis. At multivariate analysis, number of CD163+ cells, M2+ cells, and age were independent factors for poor overall survival (P = 0.03, 0.02, and 0.01, respectively). CD163+ cells and M2 cells might work to be tumor promotive in CHL. M1 cells might be tumor suppressive in mixed cellularity type.
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