期刊
VIRCHOWS ARCHIV
卷 453, 期 2, 页码 133-139出版社
SPRINGER
DOI: 10.1007/s00428-008-0643-4
关键词
Breast carcinoma; Her2-neu; p110; PIK3CA mutations
类别
资金
- Fondo de Investigaciones Sanitarias [FIS P106-0709]
- Instituto Carlos III RTICCCFIS [RD06/0020/0015]
PIK3CA mutations at 9 and 20 exons were studied in a series of 56 selected aggressive breast carcinomas (BC): 27 with Her-2 over-expression and negativity for estrogen receptors (ER) and progesterone receptors (PR), and 29 triple negative BC (negative for ER, PR and Her-2). Also, immunohistochemical studies of p53, ki-67, Her-1 (EGFR), plGF-IR, PTFN, p110 alpha, and pAkt were performed. Six mutations in exon 20 PIK3CA were identified among the 27 Her-2 positive BC, whereas only one exon 9 PIK3CA mutation was detected in a triple negative tumor (p = 0.035). Furthermore, PIK3CA mutations were associated with p110 alpha over-expression (p = 0.001). Overall Survival was shorter in cases with PIK3CA mutations (p = 0.015 in all series; and p = 0.041 for Her-2+ tumors), although multivariate analyses did not show statistical differences. No statistical significance was related with disease-free survival. Exon 20 PIK3CA mutations are relatively frequent in Her-2+ tumors and shorten survival, whereas neither exons 9 and 20 mutations seem related with triple negative breast carcinomas.
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