期刊
VIRAL IMMUNOLOGY
卷 27, 期 1, 页码 20-25出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2013.0097
关键词
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资金
- National Institute of Allergy and Infectious Diseases [U01-AI-35004, U01-AI-31834, U01-AI-34994, U01-AI-34989, U01-AI-34993, U01-AI-42590]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development [U01-HD-32632]
- National Cancer Institute
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Center for Research Resources (UCSF-CTSI) [UL1 RR024131]
- Einstein-Montefiore Center for AIDS Research [P30-AI-51519]
- Institute for Clinical and Translational Research [UL1 RR025750]
Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.
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