期刊
VETERINARY RESEARCH COMMUNICATIONS
卷 34, 期 6, 页码 519-532出版社
SPRINGER
DOI: 10.1007/s11259-010-9423-0
关键词
Biological response modifiers; Mammary gland; Involution; Bovine
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica (Argentinean Agency for Science and Technology)
- Fundacion ArgenINTA
Biological response modifiers (BRM) are compounds that interact with the immune system to regulate specific aspects of host response. The objective of this study was to describe clinical and morphological changes during involution of bovine mammary gland following a single-dose infusion of a BRM containing lipopolysaccharide and cellular fractions of Escherichia coli incorporated into liposomes. A massive leukocyte response and increased subepithelial stroma infiltration of mononuclear cells, eosinophils and mast cells was observed in BRM-treated quarters compared with untreated controls; however, morphologic parameters assessed at 11 days post infusion were indicative of only slightly accelerated involution compared with untreated controls. In addition, BRM infusion at the end of lactation did not interfere with mammary epithelial cell proliferation and caused only mild systemic effects.
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