期刊
ELIFE
卷 4, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.10719
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资金
- Deutsche Forschungsgemeinschaft (DFG) [TA 552/5-1]
- MEXT/JSPS KAKENHI [266646, 15K14307, 26840110, 25890003, 26250001, 26120705, 26119503]
- Naito Foundation
- Kurata Memorial Hitachi Science and Technology Foundation
- Uehara Memorial Foundation
- Howard Hughes Medical Institute (HHMI)
- Grants-in-Aid for Scientific Research [26250001, 25890003, 15K14307, 26840110, 26120705, 26119503] Funding Source: KAKEN
Dopamine signals reward in animal brains. A single presentation of a sugar reward to Drosophila activates distinct subsets of dopamine neurons that independently induce short- and long-term olfactory memories (STM and LTM, respectively). In this study, we show that a recurrent reward circuit underlies the formation and consolidation of LTM. This feedback circuit is composed of a single class of reward-signaling dopamine neurons (PAM-alpha 1) projecting to a restricted region of the mushroom body (MB), and a specific MB output cell type, MBON-alpha 1, whose dendrites arborize that same MB compartment. Both MBON-alpha 1 and PAM-alpha 1 neurons are required during the acquisition and consolidation of appetitive LTM. MBON-alpha 1 additionally mediates the retrieval of LTM, which is dependent on the dopamine receptor signaling in the MB alpha/beta neurons. Our results suggest that a reward signal transforms a nascent memory trace into a stable LTM using a feedback circuit at the cost of memory specificity.
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