期刊
ELIFE
卷 4, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.05808
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资金
- Agence Nationale de la Recherche
- Human Frontier Science Program (HFSP) [RGP008912009-C]
- Fondation pour la Recherche Medicale [DEC20100318242]
- Agence Nationale de la Recherche [ANR11BSV4 010, ANR P3N NanoFret2, ANR-10-LABX-54 MEMO LIFE, ANR-11-IDEX-0001-02 PSL]
- Federation pour la Recherche sur le Cerveau [AOE-6 ROTARY]
- European Research Council (ERC) [ADG_250345]
- Wellcome Trust [WT094077]
- Gatsby Charitable Foundation
The great demand for long-wavelength and high signal-to-noise Ca2+ indicators has led us to develop CaRuby-Nano, a new functionalizable red calcium indicator with nanomolar affinity for use in cell biology and neuroscience research. In addition, we generated CaRuby-Nano dextran conjugates and an AM-ester variant for bulk loading of tissue. We tested the new indicator using in vitro and in vivo experiments demonstrating the high sensitivity of CaRuby-Nano as well as its power in dual color imaging experiments.
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