期刊
VETERINARY PATHOLOGY
卷 51, 期 4, 页码 820-823出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985813505875
关键词
adverse reaction; chemical castration; dog; EsterilSol; orchitis; testicular necrosis; zinc gluconate neutralized with arginine
资金
- Sir James Dunn Animal Welfare Centre
- Alliance for Contraception in Cats and Dogs
Intratesticular injection of EsterilSol (zinc gluconate neutralized with arginine) is a chemical sterilant for male dogs sometimes used in population control campaigns. Adverse reactions have been reported in 1% to 4% of treated dogs, but detailed histomorphologic descriptions are lacking. During a behavioral study conducted in the Chilean Patagonia in 2012, severe necrosuppurative orchitis and ulcerative dermatitis were observed in 2 of 36 (6%) dogs sterilized with EsterilSol according to the manufacturer's instructions. Reactions were noted on days 8 and 7 postinjection and required scrotal ablation on days 8 and 13, respectively; neither reaction was associated with the injection site. Although self-trauma following administration may have contributed, the cause of the adverse reactions is uncertain. EsterilSol is a relatively uncomplicated method to sterilize male dogs, but the occurrence of severe adverse reactions several days after administration emphasizes the need for the provision of long-term monitoring and veterinary care during sterilization campaigns using this product.
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