期刊
VETERINARY PATHOLOGY
卷 49, 期 1, 页码 71-84出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0300985811429811
关键词
mouse embryo; embryonic lethality; placenta; histology atlas; imaging; phenotyping
资金
- National Institute of Environmental Health Sciences, National Institutes of Health
The normal embryonic development of organs and other tissues in mice and all species is preprogrammed by genes. Inactivation of a gene involved in any stage of normal embryonic development can have severe consequences leading to embryonic or postnatal developmental defects and lethality. Pathology methods are reviewed for evaluating normal and abnormal placenta and embryo, especially after E12.5. These methods include pathology protocols for necropsy and histopathology in addition to references that will provide additional knowledge for embryo assessment including histology atlases and advanced embryo imaging techniques.
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