期刊
VETERINARY PATHOLOGY
卷 46, 期 1, 页码 138-141出版社
SAGE PUBLICATIONS INC
DOI: 10.1354/vp.46-1-138
关键词
Avian influenza; H5N1; guinea pigs; pneumonia; susceptibility
资金
- National Biodefense Analysis and Countermeasures Center [RSRD-06-00051]
- Department of Homeland Security
The H5N1 high-pathogenicity avian influenza (HPAI) viruses have caused widespread disease Of Poultry in Asia, Africa and the Middle East, and sporadic human infections. The guinea pig model has been used to Study human H3N2 and H1N1 influenza viruses, but knowledge is lacking oil H5N1 HPAI Virus infections. Guinea pigs Were inoculated intranasally or intragastrically with A/ Vletnam/1203/04 (VN/04) or A/Muscovy duck/Vietnam/209/05 (MDk/VN/05) Viruses. Mild listlessness was seen Lit 2 and 3 days postinoculation (DPI) in guinea Pigs Inoculated intranasally with VN/04 virus. At 5 DPI, the guinea pigs had bronchointerstitial pneumonia and virus was identified ill bronchiolar epithelium and alveolar macrophages. Virus was isolated from the lungs but was lacking from other organs. Minimal lung lesions were seen in intranasal MDk/VN/06 group and virus was not detected, but serologic evidence of infection was observed. Intragastric exposure failed to produce infection or lesions with either virus. The localized respiratory disease in guinea pigs with H5N1 viruses was very similar to that of H3N2 and H1N1 influenza ill humans and was less severe than reported for H5N1 human cases.
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