期刊
VETERINARY PATHOLOGY
卷 46, 期 3, 页码 531-535出版社
SAGE PUBLICATIONS INC
DOI: 10.1354/vp.08-VP-0043-J-FL
关键词
Histopathologic characteristics; immunohistochemical examination; isolated Chinese strain SC19; Streptococcus suis type 2; suilysin
资金
- 973 program [2006CB504404]
- 863 program [2006AA10A206]
- National Key Technology RD Program [2006BAD06A11]
Streptococcus suds type 2 (S. suis 2) is known as a major porcine pathogen worldwide and causes meningitis, septicemia, endocarditis, arthritis, and septic shock in pigs. Suilysin, a secreted protein of S. suis 2, is considered to be an important S. sins 2 virulence-associated factor. In this paper, the cerebellar lesions following experimental infection of pigs with S. suis 2 were studied. An immunohistochemical technique was applied to compare the distribution of bacteria and secreted suilysin protein in brain. The infected pigs developed histologic lesions of meningoencephalitis. Immunohistochemistry identified bacteria within the cytoplasm of neutrophils and macrophages localized in meningeal lesions. The secreted suilysin protein showed a similar localization within the cytoplasm of inflammatory cells, indicating that suilysin had high expression in vivo and may contribute to the pathogenesis of streptococcal meningoencephalitis.
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