期刊
VETERINARY PARASITOLOGY
卷 201, 期 3-4, 页码 220-222出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2014.02.016
关键词
Afoxolaner; Dogs; Dermacentor variabilis; Ticks
资金
- Merial Limited
Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Dermacentor variabilis ticks was confirmed in two laboratory studies. Each study utilized a controlled, randomized block design. One day prior to treatment, beagle dogs were infested with 50 unfed adult ticks. Repeat infestations were performed weekly for four weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5 mg/kg) eliminated the pre-existing infestations by D. variabilis ticks and controlled weekly re-infestations with 99.7-100% efficacy up to Day 23 and >97% efficacy at Day 30. (C) 2014 The Authors. Published by Elsevier B.V.
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