期刊
VETERINARY PARASITOLOGY
卷 194, 期 1, 页码 70-74出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2013.01.003
关键词
Oxfendazole; Nematodicidal activity; Pigs
资金
- Department for International Development (DFID) UK
- Bill and Melinda Gates Foundation (BMGF)
- GALVmed (Global Alliance for Veterinary Medicines)
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris sins. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n =12 each), respectively. Each experiment involved two different groups (n=6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthice, Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post-treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp. (C) 2013 Elsevier B.V. All rights reserved.
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