期刊
VETERINARY PARASITOLOGY
卷 187, 期 3-4, 页码 538-541出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetpar.2012.01.028
关键词
Rhipicephalus microplus; VDAC; Babesia bigemina; Midgut cells; Apoptosis
资金
- CONACYT [78921]
- ICyT-DF, Mexico [ICyTDF/321/2009]
- CONACYT, Mexico [215464]
We investigated the interaction of Rhipicephalus microplus midgut cells with Babesia bigemina sexual stages using a proteomic approach. A polypeptide from the R. microplus midgut that binds to proteins from B. bigemina sexual stages was identified and sequenced. Combining 2D overlay and tandem mass spectrometry (MS/MS) techniques, we determined that this polypeptide corresponds to a mitochondrial voltage-dependent anion-selective channel (VDAC). The vdac gene encoding the sequenced polypeptide was identified and sequenced. This is the first report of a VDAC-like protein in R. microplus, and a possible role for this protein in the B. bigemina infection process is suggested. (C) 2012 Elsevier B.V. All rights reserved.
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