期刊
VETERINARY PARASITOLOGY
卷 176, 期 1, 页码 53-58出版社
ELSEVIER
DOI: 10.1016/j.vetpar.2010.10.039
关键词
Filamentous phages; Vaccination; Cysticercosis; Hydatidosis; Taenia solium; Echinococcus granulosus
资金
- Consejo Nacional de Ciencia y Tecnologia [185946]
- Fundacion Produce, Morelos A.C.
- Secretaria de Desarrollo Rural del Estado del Morelos, Mexico
- CEAMISH-Universidad Autonoma del Estado de Morelos
- LISIG-UAEM
- Municipal Authorities from Tlaquiltenango, Tepalcingo, and Ciudad Ayala, Morelos
- Xoxocotla and Direccion General de Personal Academico
- Universidad Nacional Autonoma de Mexico [IN-217908]
This paper provides macroscopic and histological evidence on the statistically significant protective effects of S3Pvac-phage vaccination against porcine cysticercosis and hydatidosis. The study included 391 rustically bred pigs (187 vaccinated and 204 controls). Vaccination significantly reduced the prevalence of cysticercosis by 61.7%. Vaccination also significantly reduced by 56.1% the prevalence of hydatidosis caused by Echinococcus granulosus in pigs. The presence of the vaccine epitopes in both cestodes is probably involved in the cross-protection observed. Increased inflammation was found in 5% of cysticerci recovered from controls, versus 24% from vaccinated pigs (P < 0.01). Hydatid cysts were non-inflammatory in either group. Vaccination was effective to prevent one single disease, but it failed to prevent the simultaneous infections with both parasites in a same pig. The widening of the S3Pvac-phage vaccine protective repertoire to include hydatidosis is a convenient feature that should reduce the prevalence of two frequent zoonoses that affect rustic porcine breading with a single action. Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses. (C) 2010 Elsevier B.V. All rights reserved.
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