期刊
VETERINARY OPHTHALMOLOGY
卷 11, 期 6, 页码 363-367出版社
WILEY
DOI: 10.1111/j.1463-5224.2008.00659.x
关键词
cat; corneal innervation; corneal nerve density; corneal nerve quantification; dog; in vivo confocal microscopy
资金
- Department of Ophthalmology, University of Rostock, Germany
- Heidelberg Engineering GmbH, Dossenheim, Germany
- Deutsche Forschungsgemeinschaft (DFG), Bonn, Germany
To determine the density of the canine and feline corneal neural network in healthy dogs and cats using in vivo confocal microscopy (IVCM). A total of 16 adult dogs (9 Mesocephalic breeds, 7 Brachycephalic breeds) and 15 cats (9 Domestic Short-haired cats (DSH), 6 Persian cats) underwent IVCM. Animals were examined with a confocal corneal microscope (HRTII/RCM; Heidelberg Retina Tomograph II/Rostock Cornea Module((R)), Heidelberg Engineering, Dossenheim, Germany). The investigations focused on the distribution of the corneal nerves and quantification of central subepithelial and subbasal nerve plexus. The corneal stromal nerve trunks, subepithelial and subbasal nerve plexus were observed. The nerve fiber density (NFD) quantified in nerve fiber length in mesocephalic dogs were 12.39 +/- 5.25 mm/mm(2) in the subepithelial nerve plexus and 14.87 +/- 3.08 mm/mm(2) in the subbasal nerve plexus. The NFD of the subepithelial nerve plexus in DSH cats was 15.49 +/- 2.7 and 18.4 +/- 3.84 mm/mm(2) in the subbasal nerve plexus. The subbasal NFD of DSH cats was significantly higher than in mesocephalic dogs (P = 0.037). The subepithelial NFD in brachycephalic dogs, and Persian cats were 10.34 +/- 4.71 and 9.50 +/- 2.3 mm/mm(2), respectively. The subbasal NFD measured 11.80 +/- 3.73 mm/mm(2) in brachycephalic dogs, and 12.28 +/- 4.3 mm/mm(2) NFD in Persian cats, respectively. The subepithelial and subbasal NFD in Persian cats were significantly lower than in DSH cats (P = 0.028, respectively, P = 0.031), in contrast to brachycephalic vs. mesocephalic dogs. The noninvasive IVCM accurately detects corneal innervation and provides a reliable quantification of central corneal nerves.
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