期刊
VETERINARY OPHTHALMOLOGY
卷 11, 期 5, 页码 290-298出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1463-5224.2008.00649.x
关键词
cataract; electroretinography; microbeam radiation therapy (MRT); retinopathy; synchrotron
资金
- Saskatchewan Health Research Foundation (SHRF)
Objectives To describe the chronic ocular lesions associated with microbeam radiation therapy (MRT) in an experimental rat study. Procedures MRT was administered bi-directionally with a skin entry dose of 350 Gy. During laterally directed irradiation, the beam entered the head on the right with the center of the beam array 3 mm posterior to the center of the right eye. During irradiation in anterior-posterior direction, the right eye was almost completely in the path of the beam array. Twelve months after MRT ophthalmic examinations were completed on 37 treated (MRT+) and 16 control (MRT-) rats. Electroretinography (ERG) was completed in two MRT+ and one MRT- rat. Histopathology was performed on eyes of 16 MRT+ and 9 MRT- rats, and retinal and choroidal thicknesses were measured. Results Biomicroscopic and indirect ophthalmoscopic examinations revealed fundus pallor and retinal vascular attenuation in 33 of 37 right and 2 of 37 left eyes of MRT+ rats. Cataracts were present in the right eyes of 12 of 37 MRT+ rats. ERG amplitudes were reduced in the eyes of MRT+ rats. Light microscopy revealed retinal lesions ranging in severity with loss of outer to inner retinal cell layers, in 16 of 16 right and of 8 of 16 left eyes MRT+ rats. The mean right retinal thickness of MRT+ rats was reduced. Conclusions Eyes within the field treated with MRT at a dose of 350 Gy develop retinal degeneration and occasionally, cataract.
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