期刊
VETERINARY MICROBIOLOGY
卷 152, 期 1-2, 页码 55-66出版社
ELSEVIER
DOI: 10.1016/j.vetmic.2011.04.015
关键词
Group A rotaviruses; Gastroenteritis; Bovine; Reassortment; Genotype constellations
资金
- National Veterinary Research and Quarantine Services (NVRQS)
- Ministry for Food, Agriculture, Forestry and Fisheries
- Korea Science and Engineering Foundation (KOSEF) [2009-0081752]
- Ministry of Commerce, Industry and Energy (MOCIE) Republic of Korea
- Korean Ministry of Education and Human Resources Development
- FWO ('Fonds voor Wetenschappelijk Onderzoek')
- National Research Foundation of Korea [2009-0081752] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Group A rotaviruses (GARVs) cause severe acute gastroenteritis in children and young animals. Although zoonotic infections with bovine-like G6 and G8 GARVs have been reported in many countries, there is little evidence for reassortment between bovine GARVs and GARVs from heterologous species. The finding of bovine GARVs with the G6 and G8 genotypes in combination with the typical porcine P[7] prompted us to characterize all 11 genes of 30 bovine GARVs isolated from clinically infected calves. By the comparison of the full-length ORF of VP7 and NSP1-5, and the partial VP1-4 and VP6 nucleotide sequences between the 30 Korean and other known strains, three different genome constellations were found. Twenty seven strains showed the G8-P[7]-I5-R1-C1-M2-A1-N1-T1-E1-H1 genotypes, a single strain possessed the G6-P[7]-I2-R2-C1-M2-A1-N2-T1-E2-H1 genotype constellation and 2 strains the G6-P[7]-I2-R2-C2-M2-A3-N2-T6-E2-H3 genotype constellation. The complete genome of a single reference strains for each of these three genotype constellations (KJ25. KJ9-1 and KJ19-2) was determined and analyzed. A detailed phylogenetic analysis revealed a complicated picture, with several reassortments among bovine-like, porcine-like and human-like GARV strains, resulting in several different reassortant strains successfully infecting cattle. (C) 2011 Elsevier B.V. All rights reserved.
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