期刊
VETERINARY MICROBIOLOGY
卷 148, 期 2-4, 页码 298-307出版社
ELSEVIER
DOI: 10.1016/j.vetmic.2010.09.006
关键词
Salmonella Enteritidis; Vaccination; Type 3 secretion systems
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Bioniche Life Sciences Inc.
- NSERC Senior Industrial Research Chair
- NSERC Associate Industrial Research Chair
- Saskatchewan Health Research Foundation (SHRF)
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a major cause of gastrointestinal disease in humans worldwide, which mainly results from the consumption of contaminated poultry meat and eggs. Vaccination of chickens is an important strategy to lower the prevalence of Salmonella in poultry flocks. The S. Enteritidis type 3 secretion system (T3SS) encoded on Salmonella pathogenicity island-1 (SPI-1) is an important virulence factor that plays a role in invasion and systemic spread in chickens. In this manuscript, we evaluated the efficacy of SPI-1 proteins as vaccine candidates for protection against S. Enteritidis oral challenge. Our results demonstrate for the first time that SPI-1 T3SS proteins elicit antigen specific IgG antibody responses in chickens. In one study we show that vaccination with the aforementioned proteins reduces the levels of S. Enteritidis in the liver, but not in the spleen and cecal contents of chickens. However, a second study shows that vaccination of hens with SPI-1 proteins using a seeder model of infection does not affect the levels of S. Enteritidis in the cecal contents or internal organs of progeny obtained from these hens. Hence, the SPI-1 proteins, in conjunction with other proteins, may form important components of subunit vaccines used for protection against colonization by S. Enteritidis in poultry. (C) 2010 Elsevier B.V. All rights reserved.
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