期刊
VETERINARY MICROBIOLOGY
卷 146, 期 3-4, 页码 346-349出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2010.05.031
关键词
Low pathogenic avian influenza viruses; 2009 pandemic influenza A (H1N1) virus; Erythrocytes; Hemagglutination assay
资金
- Centers for Disease Control and Prevention (CDC) [1U19CI00399-01]
- Thailand Research Fund for Senior Research Scholars
All 16 subtypes of avian influenza viruses of low pathogenicity (LPAIV) as well as their hemagglutinin (H) antigens, and four 2009 pandemic influenza A (H1N1) virus isolates were assayed for hemagglutinating activity against 5 erythrocyte species: goose, guinea pig, human group O, chicken and horse. Of all viruses and antigens assayed, the highest hemagglutination (HA) titers were obtained with goose and guinea pig erythrocytes. Hemagglutinating activity of replicating LPAIV and LPAIV antigens decreased, in order, with chicken and human group O; meanwhile, horse erythrocytes yielded lowest or no HA titer. Moreover, the 2009 pandemic viruses did not agglutinate both horse and chicken erythrocytes. Our study concluded that goose and guinea pig erythrocytes are the best in HA assay for all subtypes of influenza viruses. (C) 2010 Elsevier B.V. All rights reserved.
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