期刊
VETERINARY MICROBIOLOGY
卷 139, 期 3-4, 页码 333-338出版社
ELSEVIER
DOI: 10.1016/j.vetmic.2009.06.029
关键词
Staphylococcus pseudintermedius; Methicillin resistance; Multilocus sequence type; Pulsed-field gel electrophoresis; Staphylococcal chromosomal cassette mec type V-T
资金
- Center of Excellence in Livestock Diseases and Human Health, University of Tennessee
- Culture and Education Bureau of the Arab Republic of Egypt
Methicillin resistance encoded by the mecA gene is increasingly observed in Staphylococcus pseudintermedius. Little is known about the population genetics of,veterinary staphylococci bearing methicillin resistance. The aim of this study was to determine the relatedness of resistant bacteria and to compare them with methicillin-susceptible isolates. Multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE) fragment profiling were performed on methicillin-resistant S. pseudintermedius (MRSP) and methicillin-susceptible S. pseudintermedius (MSSP) isolates obtained from canine samples submitted to the veterinary teaching hospital bacteriology service between 2006 and 2008. Multilocus sequence typing detected 20 different sequence types, 16 of which were not previously described. Methicillin-resistant isolates were predominantly ST 68, possessed the Staphylococcus aureus-associated staphylococcal chromosomal cassette mec (SCCmec) type V-T and fell within the largest PFGE cluster; whereas methicillin-susceptible strains were more genetically diverse. This suggests that most methicillin resistance within the population of isolates tested originated from a single source which has persisted and expanded for several years. (C) 2009 Elsevier B.V. All rights reserved.
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