期刊
VETERINARY JOURNAL
卷 178, 期 2, 页码 291-293出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tvjl.2007.08.014
关键词
Bleomycin; Biphasic pulse; Cisplatin; Electrochemotherapy
资金
- Italian Ministry of Health
- FUTURA-onlus
- Second University of Naples
An 8-year-old male castrated cat was referred for Sudden onset of lameness. Physical examination revealed a 1 x 2 x 1 cm mass originating from a footpad of the right hind leg. A diagnosis of ganglioneuroblastoma Was Suggested by the tumour appearance following histopathological staining with haematoxylin and eosin and haematoxylin/van Gieson. Immunohistochemical staining for glial fibrillary acidic protein (GFAP), vimentin, neuron-specific enolase (NSE), neurofilament and S100 further confirmed the diagnosis. The staging process did not indicate metastatic spread. The cat was treated with three sessions of electrochemotherapy (ECT) 1 week apart, following local injection of bleomycin. The tumour had completely regressed within 1 week of the third ECT application and remained in remission for 402 days at which time a small recurrence was noted. The animal was given a further session of ECT using intra-lesional cisplatin and again went into remission. It remained tumour free at 450 days. Electrochemotherapy is considered a safe and effective treatment for localised neoplasms of cats and dogs and warrants further investigation. (C) 2007 Elsevier Ltd. All rights reserved.
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