期刊
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
卷 145, 期 1-2, 页码 551-555出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetimm.2011.12.013
关键词
African swine fever virus; Atypical lymphocyte; Infection; Interferon
资金
- Armenian National Science and Educational Fund [NS-2532]
African swine fever virus (ASFV) is the causative agent of African swine fever that is the significant disease of domestic pigs, with high rates of mortality. ASFV is double-stranded DNA virus whose genes encode some proteins that are implicated in the suppression of host immune response. In this study, we have modeled in vivo infection of ASFV for determination of interferon (IFN) status in infected pigs. We measured the level of IFN-alpha, -beta and -gamma by enzyme-linked immunosorbent assay and showed that the level of IFN-alpha sharply decreased during infection. Unlike IFN-alpha, the level of IFN-beta and -gamma increased from the 2nd and 4th days post-infection, respectively. Also, we analyzed the population dynamics of peripheral white blood cells of infected pigs due to their important role in host immune system. We showed that the atypical lymphocytes appeared after short time of infection and this result is in accordance with our previous study done in vitro. At the last day of infection about 50% of the total white blood cells were destroyed, and the remaining cells were represented mainly by small-sized lymphocytes, reactive lymphocytes and lymphoblasts. (C) 2011 Elsevier B.V. All rights reserved.
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